Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction
Identifieur interne : 001077 ( Main/Exploration ); précédent : 001076; suivant : 001078Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction
Auteurs : Ibtissam Marchiq [France] ; Jean Albrengues [France] ; Sara Granja [Portugal] ; Cédric Gaggioli [France] ; Jacques Pouysségur [France] ; Marie-Pierre Simon [France]Source :
- Oncotarget [ 1949-2553 ] ; 2015.
Abstract
BASIGIN/CD147/EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours. BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. However, before being recognized as a co-carrier of MCTs, BASIGIN was described as an inducer of extracellular matrix metalloproteases (MMPs). Early on, a model emerged in which, tumour cells use the extracellular domain of BASIGIN to recognize and stimulate neighbouring fibroblasts to produce MMPs. However, this model has remained hypothetical since a direct link between BASIGIN and MMPs production has not yet been clearly established. To validate the BASIGIN/MMP hypothesis, we developed BASIGIN knockouts in three human tumour cell lines derived from glioma, colon, and lung adenocarcinoma. By using co-culture experiments of either human or mouse fibroblasts and tumour cell lines we showed, contrary to what has been abundantly published, that the disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs. Our findings do not support the notion that the pro-tumoural action of BASIGIN is mediated
Url:
PubMed: 26284589
PubMed Central: 4694784
Affiliations:
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Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea> Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, Braga</wicri:regionArea><orgName type="university">Université du Minho</orgName><placeName><settlement type="city">Braga</settlement><region>Région Nord (Portugal)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea> ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães</wicri:regionArea><wicri:noRegion>Braga/Guimarães</wicri:noRegion></affiliation></author><author><name sortKey="Gaggioli, Cedric" sort="Gaggioli, Cedric" uniqKey="Gaggioli C" first="Cédric" last="Gaggioli">Cédric Gaggioli</name><affiliation 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wicri:level="3"><nlm:aff id="A1"> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Centre Antoine Lacassagne, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Centre Antoine Lacassagne, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Albrengues, Jean" sort="Albrengues, Jean" uniqKey="Albrengues J" first="Jean" last="Albrengues">Jean Albrengues</name><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Medical School, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Medical School, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Granja, Sara" sort="Granja, Sara" uniqKey="Granja S" first="Sara" last="Granja">Sara Granja</name><affiliation wicri:level="4"><nlm:aff id="A3"> Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea> Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, Braga</wicri:regionArea><orgName type="university">Université du Minho</orgName><placeName><settlement type="city">Braga</settlement><region>Région Nord (Portugal)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea> ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães</wicri:regionArea><wicri:noRegion>Braga/Guimarães</wicri:noRegion></affiliation></author><author><name sortKey="Gaggioli, Cedric" sort="Gaggioli, Cedric" uniqKey="Gaggioli C" first="Cédric" last="Gaggioli">Cédric Gaggioli</name><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Medical School, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Medical School, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Pouyssegur, Jacques" sort="Pouyssegur, Jacques" uniqKey="Pouyssegur J" first="Jacques" last="Pouysségur">Jacques Pouysségur</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Centre Antoine Lacassagne, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Centre Antoine Lacassagne, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A5"> Centre Scientifique de Monaco (CSM), Quai Antoine Ier MC, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre Scientifique de Monaco (CSM), Quai Antoine Ier MC</wicri:regionArea><wicri:noRegion>Quai Antoine Ier MC</wicri:noRegion><wicri:noRegion>Quai Antoine Ier MC</wicri:noRegion></affiliation></author><author><name sortKey="Simon, Marie Pierre" sort="Simon, Marie Pierre" uniqKey="Simon M" first="Marie-Pierre" last="Simon">Marie-Pierre Simon</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Centre Antoine Lacassagne, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, CNRS, Institute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, Centre Antoine Lacassagne, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>BASIGIN/CD147/EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours. BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. However, before being recognized as a co-carrier of MCTs, BASIGIN was described as an inducer of extracellular matrix metalloproteases (MMPs). Early on, a model emerged in which, tumour cells use the extracellular domain of BASIGIN to recognize and stimulate neighbouring fibroblasts to produce MMPs. However, this model has remained hypothetical since a direct link between BASIGIN and MMPs production has not yet been clearly established. To validate the BASIGIN/MMP hypothesis, we developed BASIGIN knockouts in three human tumour cell lines derived from glioma, colon, and lung adenocarcinoma. By using co-culture experiments of either human or mouse fibroblasts and tumour cell lines we showed, contrary to what has been abundantly published, that the disruption of BASIGIN in tumour cells and in MEFs has no action on the production of MMPs. Our findings do not support the notion that the pro-tumoural action of BASIGIN is mediated <italic>via</italic> induction of MMPs. Therefore, we propose that to date, the strongest pro-tumoural action of BASIGIN is mediated through the control of fermentative glycolysis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agrawal, Sm" uniqKey="Agrawal S">SM Agrawal</name></author><author><name sortKey="Yong, Vw" uniqKey="Yong V">VW Yong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muramatsu, T" uniqKey="Muramatsu T">T Muramatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weidle, Uh" uniqKey="Weidle U">UH Weidle</name></author><author><name sortKey="Scheuer, W" uniqKey="Scheuer W">W Scheuer</name></author><author><name sortKey="Eggle, D" uniqKey="Eggle D">D Eggle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Chiche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parks, Sk" uniqKey="Parks S">SK Parks</name></author><author><name sortKey="Chiche, J" uniqKey="Chiche J">J Chiche</name></author><author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szymanowska, M" uniqKey="Szymanowska M">M Szymanowska</name></author><author><name sortKey="Hendry, Ka" uniqKey="Hendry K">KA Hendry</name></author><author><name sortKey="Robinson, C" uniqKey="Robinson C">C Robinson</name></author><author><name sortKey="Kolb, Af" uniqKey="Kolb A">AF Kolb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Philp, Nj" uniqKey="Philp N">NJ Philp</name></author><author><name sortKey="Ochrietor, Jd" uniqKey="Ochrietor J">JD Ochrietor</name></author><author><name sortKey="Rudoy, C" uniqKey="Rudoy C">C Rudoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaffney, J" uniqKey="Gaffney J">J Gaffney</name></author><author><name sortKey="Solomonov, I" uniqKey="Solomonov I">I Solomonov</name></author><author><name sortKey="Zehorai, E" uniqKey="Zehorai E">E Zehorai</name></author><author><name sortKey="Sagi, I" uniqKey="Sagi I">I Sagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granja, S" uniqKey="Granja S">S Granja</name></author><author><name sortKey="Marchiq, I" uniqKey="Marchiq I">I Marchiq</name></author><author><name sortKey="Baltazar, F" uniqKey="Baltazar F">F Baltazar</name></author><author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bilton, R" uniqKey="Bilton R">R Bilton</name></author><author><name sortKey="Trottier, E" uniqKey="Trottier E">E Trottier</name></author><author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name></author><author><name sortKey="Brahimi Horn, Mc" uniqKey="Brahimi Horn M">MC Brahimi-Horn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albrengues, J" uniqKey="Albrengues J">J Albrengues</name></author><author><name sortKey="Bourget, I" uniqKey="Bourget I">I Bourget</name></author><author><name sortKey="Pons, C" uniqKey="Pons C">C Pons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hooper, S" uniqKey="Hooper S">S Hooper</name></author><author><name sortKey="Gaggioli, C" uniqKey="Gaggioli C">C Gaggioli</name></author><author><name sortKey="Sahai, E" uniqKey="Sahai E">E Sahai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Portugal</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Région Nord (Portugal)</li></region><settlement><li>Braga</li><li>Nice</li></settlement><orgName><li>Université du Minho</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Marchiq, Ibtissam" sort="Marchiq, Ibtissam" uniqKey="Marchiq I" first="Ibtissam" last="Marchiq">Ibtissam Marchiq</name></region><name sortKey="Albrengues, Jean" sort="Albrengues, Jean" uniqKey="Albrengues J" first="Jean" last="Albrengues">Jean Albrengues</name><name sortKey="Gaggioli, Cedric" sort="Gaggioli, Cedric" uniqKey="Gaggioli C" first="Cédric" last="Gaggioli">Cédric Gaggioli</name><name sortKey="Pouyssegur, Jacques" sort="Pouyssegur, Jacques" uniqKey="Pouyssegur J" first="Jacques" last="Pouysségur">Jacques Pouysségur</name><name sortKey="Pouyssegur, Jacques" sort="Pouyssegur, Jacques" uniqKey="Pouyssegur J" first="Jacques" last="Pouysségur">Jacques Pouysségur</name><name sortKey="Simon, Marie Pierre" sort="Simon, Marie Pierre" uniqKey="Simon M" first="Marie-Pierre" last="Simon">Marie-Pierre Simon</name></country><country name="Portugal"><region name="Région Nord (Portugal)"><name sortKey="Granja, Sara" sort="Granja, Sara" uniqKey="Granja S" first="Sara" last="Granja">Sara Granja</name></region><name sortKey="Granja, Sara" sort="Granja, Sara" uniqKey="Granja S" first="Sara" last="Granja">Sara Granja</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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